found the involvement of the left prefrontal cortex (PFC) and dorsal anterior cingulate cortex and also the bilateral involvement of posterior parietal cortex, caudate nuclei, fusiform, and frontal eye field areas while solving the simplified version of Sudoku puzzle. Simplified versions of Sudoku (4 × 4 matrix) have been used in various functional magnetic resonance imaging (fMRI) studies. Many studies have been directed toward finding an algorithm to solve Sudoku, but the investigation of the neural substrates involved in Sudoku has been challenging. However, little is known about the neural substrates involved during Sudoku. ![]() Since solving Sudoku involves executive cognitive functions, most importantly problem-solving and decision-making, it can be a promising tool for neurorehabilitation and cognitive remediation therapy in neuropsychiatric disorders. Cognitive deficits are important features among many neuropsychiatric disorders such as depression, bipolar disease, schizophrenia, Parkinson’s and Alzheimer’s disease with dysfunctions in working memory, attention, reasoning, decision-making, and problem-solving. Solving puzzles has long been thought to keep the brain healthy and has been shown to delay the onset of dementia. Sudoku requires attention of the subject to analyze the grids and fill in the numbers basically it requires no math but is based on logic. ![]() Sudoku is a good cognitively stimulating leisure-time activity. The problem is based on three simple rules that the numbers should not repeat in the subgrid, row, or column. Popular among these puzzles is Sudoku, a logic-based combinatorial number placement problem composed of a matrix with rows ( n 2), columns ( n 2), and subgrids ( n × n). One of the most common leisure-time activities for all ages is solving puzzles.
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